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Graph-representation of oxidative folding pathways |
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| Authors: | Vilmos?ágoston Masa?Cemazar László?Kaján |
| Institution: | 1.Bioinformatics Group, Biological Research Center,Hungarian Academy of Sciences,Szeged,Hungary;2.Protein Structure and Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology,Area Science Park,Trieste,Italy;3.Institute for Molecular Bioscience,University of Queensland,St. Lucia,Australia |
| Abstract: | BackgroundThe process of oxidative folding combines the formation of native disulfide bond with conformational folding resulting in the native three-dimensional fold. Oxidative folding pathways can be described in terms of disulfide intermediate species (DIS) which can also be isolated and characterized. Each DIS corresponds to a family of folding states (conformations) that the given DIS can adopt in three dimensions. |
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