Inhibition of prostaglandin synthesis in mouse 3T3 fibroblasts and human platelets by substituted phenols |
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Authors: | Jan ke Lindgren Hans-Erik Claesson Sven Hammarstrm |
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Institution: | Department of Chemistry, Karolinska Institutet S-104 01 Stockholm, Sweden |
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Abstract: | Several substituted phenols with antioxidant properties were potent reversible inhibitors of prostaglandin synthesis in 3T3 cell cultures. The ID50's for prostaglandin (PG) E2 synthesis in these cells were 0.1 μM for 2,6-xylenol, 5 μM for tricresol, 6 μM for
-cresol, 7 μM for
-cresol, 15 μM for 3,5-xylenol, 30 μM for
-cresol and 100 μM for phenol. The corresponding values for aspirin and indomethacin were 4 μM and 0.02 μM, respectively.The substituted phenols also inhibited serotonin release, aggregation and prostaglandin synthesis in human platelets induced by arachidonic acid but not by PGG2. |
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