铜绿假单胞菌的分布特点耐药性分析

目的分析3年来我院患者铜绿假单胞菌的耐药特点，为临床合理用药提供依据，并有助于医院感染预防与控制。方法对2010年至2012年我院各类感染患者标本中分离获得的铜绿假单胞菌，采用纸片扩散法（K-B法）检测抗菌药物的敏感性，并用WHONET5．3软件对药敏结果进行统计分析。结果3年分离的铜绿假单胞菌共计369株，其对多黏菌素B无耐药，对亚胺培南、美罗培南、头孢哌酮／舒巴坦、哌拉西彬他唑巴坦和阿米卡星的耐药率较低（6．81％～22．73％），对其他抗菌药物的耐药率较高（32．47％～73．38％）。结论铜绿假单胞菌对多种抗菌药物均具有较高的耐药性，临床上治疗该菌感染时应根据药敏检测结果选择抗菌药物。

The distribution and drug resistance of Pseudomonas aeruginosa

Objective To analyze the drug-resistance of Pseudomonas aeruginosa in our hospital in recent 3 years, provide scientific basis for safe use of drugs, and contribute to the prevention and control of nosocomial infections. Methods Disc diffusion method was used to test the susceptibility of Pseudomonas aeruginosa isolated in our hos- pital during 2010 to 2012 to common used antibiotics. The results were analyzed with WHONET 5.3 software in personal microcomputer. Results 369 strains of Pseudomonas aeruginosa were isolated. They showed no resist- ance to polymyxin B （PMB）, low resistance rates （6.81% to 22.73% ） to imipenem, meropenem, cefoperazone/ sulbactam, piperacillin/tazobactam and amikacin, and high resistance rates （32.47% to 73.38% ） to other anti- bacterial agents. Conclusion Pseudomonas aeruginosa is resistant to multiple antimicrobial drugs; Selection of antibiotics should be based on the detection results of the druz-resistance.