Somatostatinergic projections from the central nucleus of the amygdala to the vagal nuclei |
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Authors: | G A Higgins J S Schwaber |
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Institution: | Central Research and Development, E. I. du Pont de Nemours and Company 500 S. Ridgeway Avenue, Glenolden, PA 19036 USA |
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Abstract: | In the rat, somatostatin immunoreactivity was identified in neurons of the central nucleus of the amygdala that were retrogradely labeled by injection of fluorescent dyes into the nucleus tractus solitarius and dorsal motor nucleus of the vagus nerve. The double-labeled neurons are located in the medial subdivision of the central nucleus and appear to comprise less than one fifth of the descending pathway. These results suggest that somatostatin may act as a neurotransmitter in a pathway which mediates cardiovascular and other autonomic responses to fear-producing and other emotional stimuli. |
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Keywords: | Somatostatin Central nucleus of the amygdala Nucleus tractus solitarius Double-labeling methodology |
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