On the molecular mechanism of GC content variation among eubacterial genomes |
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Authors: | Hao Wu Zhang Zhang Songnian Hu and Jun Yu |
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Institution: | (1) James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou, 310007, China;(2) CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China |
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Abstract: | Background As a key parameter of genome sequence variation, the GC content of bacterial genomes has been investigated for over half a
century, and many hypotheses have been put forward to explain this GC content variation and its relationship to other fundamental
processes. Previously, we classified eubacteria into dnaE-based groups (the dimeric combination of DNA polymerase III alpha
subunits), according to a hypothesis where GC content variation is essentially governed by genome replication and DNA repair
mechanisms. Further investigation led to the discovery that two major mutator genes, polC and dnaE2, may be responsible for genomic GC content variation. Consequently, an in-depth analysis was conducted to evaluate various
potential intrinsic and extrinsic factors in association with GC content variation among eubacterial genomes. |
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