An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics |
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| Authors: | Jain P Nagaraja V |
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| Institution: | (1) Department of Microbiology and Cell Biology, Indian Institute of Science, 560 012 Bangalore, India |
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| Abstract: | DNA gyrase is an essential topoisomerase found in all bacteria. It is encoded bygyrB andgyrA genes. These genes are organized differently in different bacteria. Direct comparison ofMycobacterium tuberculosis andMycobacterium smegmatis genomes reveals presence of an additionalgyrB inM. smegmatis flanked by novel genes. Analysis of the amino acid sequence of GyrB from different organisms suggests that the orphan GyrB
inM. smegmatis may have an important cellular role. |
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| Keywords: | Mycobacterium smegmatis gyr genes DNA gyrase topoisomerase comparative genomics |
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