| 丁酸钠对人胃腺癌MGC-803细胞核仁纤维中心和银染蛋白的影响 |
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| 引用本文： | 吕桂芝,高燕,周立新,林仲翔,郑宇.丁酸钠对人胃腺癌MGC-803细胞核仁纤维中心和银染蛋白的影响[J].分子细胞生物学报,1991(4). |
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| 作者姓名： | 吕桂芝 高燕 周立新 林仲翔 郑宇 |
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| 作者单位： | 北京市肿瘤防治研究所细胞生物学室
(吕桂芝，高燕，周立新，林仲翔)，北京医科大学细胞分析室(郑宇) |
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| 摘 要： | 用透射电镜观察到MGC-803细胞的核仁是网织型的,在网眼内分布有电子密度低的纤维中心。MGC-803细胞经丁酸钠作用后,其核仁的类型发生了改变,多呈环型的,核仁的中央有一个大的纤维中心;纤维中心和银染颗粒的大小和数目明显减低;用图像分析仪测得核仁银染蛋白所占面积与核总面积的比值也明显降低。结果提示:丁酸钠可能通过抑制rRNA合成和rDNA转录活性调控MGC-803细胞的增殖。
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| 关 键 词： | 人胃腺癌细胞 丁酸钠 核仁 纤维中心 银染蛋白 |
THE EFFECTS OF SODIUM BUTYRATE (NABT) ON FIBRILLAR CENTRES AND AG-STAINING PROTEIN OF NUCLEOLUS OF HUMAN STOMACH GLANDULAR CARCINOMA (MGC-803) CELLS |
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| Abstract: | The changes in the ultrastructure of fibrillar centres, morphological type of nucleolus, and the content of Ag-nucleolus protein of Sodium Butyrate treated MGC-803 cells have been studied. It was found that the number of fibrillar centres and Ag-staining granules, content of Ag-staining protein of nucleolus were decreased, and nucleolar morphological type was changed from reticulated to ring-shaped in NaBT treated MGC-803 cells.These results indicate that NaBT regulate the proliferation and differentiation of cells by inhibiting rRNA synthesis and rDNA transeriptional activity. |
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| Keywords: | MGC-893 cells Sodium Butyrate (NaBT) Nucleolus Fibrillar centre Agstaining protein |
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