Origin and Possible Mode of Action of a Tissue Antagonist of Interferon |
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Authors: | F. FOURNIER C. CHANY M. SARRAGNE |
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Affiliation: | 1.Institut National de la Santé et de la Recherche Médicale, Unité de Recherches sur les Virus, H?pital Saint-Vincent-de-Paul,Paris |
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Abstract: | WE have presented data1 supporting the hypothesis proposed by Taylor2 and by Friedman and Sonnabend3 that interferon acts through a protein which confers the antiviral state on the cell. We postulated two separate regulatory mechanisms: one governing interferon synthesis and the other the production and action of the antiviral protein in the cell4. Our studies on the regulation of the antiviral state led us to the demonstration of a substance in human amniotic and chorionic membranes which, when added to the cell 4–18 h after interferon, decreased the antiviral state5. The extraction and purification of this tissue antagonist of interferon (TAI) have been previously described. TAI was resistant to proteases (trypsin, pepsin) and to nucleases (RNAase, DNAase). It was also resistant to heating at 56° C or 75° C for 1 h and was only inactivated at 95° C. Although the biologically active component was not chemically defined, its properties were reminiscent of mucopolysaccharides. It is unknown at present whether the TAI represents a substance or a group of substances. |
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