Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance |
| |
Authors: | Kline T Trent M S Stead C M Lee M S Sousa M C Felise H B Nguyen H V Miller S I |
| |
Institution: | Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. |
| |
Abstract: | Three sets of novel 4-deoxy-l-arabinose analogs were synthesized and evaluated as potential inhibitors of the bacterial resistance mechanism in which lipid A, on the outer membrane, is modified with 4-amino-4-deoxy-l-arabinose (l-Ara4N). One compound diminished the transfer of l-Ara4N onto lipid A. These results suggest that small molecules might be designed that would effect the same reversal of bacterial resistance observed in genetic knockouts. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |