Intracellular cAMP levels in normal rat mammary gland and adenocarcinoma. In vivo vs in vitro. |
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Authors: | L A Cohen P C Chan |
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Affiliation: | Division of Molecular Biology and Pharmacology Naylor Dana Institute for Disease Prevention 2 East End Avenue, New York, N. Y. 10021, USA |
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Abstract: | Intracellular cAMP levels determined by radioimmunoassay technique were compared in normal rat mammary gland and DMBA-induced mammary adenocarcinoma as well as in epithelial cells derived from these tissues and grown in monolayer cultures. It was found that cAMP levels were higher in mammary tumors (0.643 p mole/mg wet weight) than in normal gland (0.158 p mole/mg). In contrast, cAMP levels in cultured adenocarcinoma cells were lower than those in normal mammary epithelial cells. The apparent contradiction may be a consequence of the fact that cAMP values represent the average value of the composite cell types and not the epithelial components in question. |
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