Ba2+ current oscillation evoked by bradykinin in ras-transformed fibroblasts. |
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| Authors: | H Higashida N Hoshi M Hashii T Fu M Noda Y Nozawa |
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| Affiliation: | Department of Biophysics, Kanazawa University School of Medicine, Japan. |
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| Abstract: | By voltage-clamp recording, we show a novel inward current which oscillates after activation with bradykinin or serum in v-Ki-ras-transformed NIH/3T3 cells. The current oscillation was infrequently observed in control NIH/3T3 fibroblasts. The same stimulation evokes Ca2+ oscillations in the ras-transformed cells but not in parental cells (Fu et al., FEBS Lett. 281, 263-266, 1991). The results suggest that the oscillatory currents are generated by influxes of divalent cations to maintain Ca2+ oscillations in ras-transformed NIH/3T3 cells. |
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