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Cholesterol synthesis in rat intestine: effect of fasting and of porphyrogenic chemical allylisopropylacetamide |
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| Authors: | A Sanghvi C Wight R Balachandran I Frantz M Ener L Taddeini |
| Institution: | 1. Division of Clinical Chemistry, Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA;2. Departments of Medicine St. Paul-Ramsey Hospital and University of Minnesota Hospitals, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA |
| Abstract: | (a) Administration of allylisopropylacetamide to fasting rats stimulates intestinal sterol synthesis as measured by incorporation of 14C from 1-14C]sodium acetate. Stimulatory effect of AIA is confined to the acetate to mevalonate segment of cholesterol biosynthetic pathway.(b) It is also shown that the suppression of sterol synthesis in the ileum of intact rats produced by fasting is of the same order of magnitude as that observed for liver sterol synthesis due to fasting. |
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