Phylogeny and expression of carbonic anhydrase-related proteins |
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| Authors: | Ashok Aspatwar Martti EE Tolvanen Seppo Parkkila |
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| Institution: | (1) Bioinformatics Group, Institute of Medical Technology, 33014 University of Tampere, Tampere, Finland;(2) Institute of Medical Technology and School of Medicine, University of Tampere, 33520 Tampere, Finland;(3) Centre for Laboratory Medicine, Tampere University Hospital, 33520 Tampere, Finland |
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| Abstract: | Background Carbonic anhydrases (CAs) are found in many organisms, in which they contribute to several important biological processes.
The vertebrate α-CA family consists of 16 subfamilies, three of which (VIII, X and XI) consist of acatalytic proteins. These
are named carbonic anhydrase related proteins (CARPs), and their inactivity is due to absence of one or more Zn-binding histidine
residues. In this study, we analyzed and evaluated the distribution of genes encoding CARPs in different organisms using bioinformatic
methods, and studied their expression in mouse tissues using immunohistochemistry and real-time quantitative PCR. |
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