Controlled spatial and conformational display of immobilised bone morphogenetic protein-2 and osteopontin signalling motifs regulates osteoblast adhesion and differentiation in vitro |
| |
| Authors: | Elizabeth A Mitchell Benjamin T Chaffey Andrew W McCaskie Jeremy H Lakey Mark A Birch |
| |
| Affiliation: | (1) Institute for Cellular Medicine, The Medical School, Newcastle University, Newcastle-upon-Tyne, NE2 4HH, UK;(2) Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle-upon-Tyne, NE2 4HH, UK |
| |
| Abstract: | Background The interfacial molecular mechanisms that regulate mammalian cell growth and differentiation have important implications for biotechnology (production of cells and cell products) and medicine (tissue engineering, prosthetic implants, cancer and developmental biology). We demonstrate here that engineered protein motifs can be robustly displayed to mammalian cells in vitro in a highly controlled manner using a soluble protein scaffold designed to self assemble on a gold surface. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
