Renal tissue reconstitution by the implantation of renal segments on biodegradable polymer scaffolds |
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| Authors: | Sang-Soo Kim Heung Jae Park Joungho Han Cha Yong Choi Byung-Soo Kim |
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| Affiliation: | (1) Department of Chemical Engineering, Hanyang University, Seoul, Korea;(2) Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul, Korea;(3) Department of Urology, Kangbuk Samsung Hospital, Korea;(4) Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
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| Abstract: | Renal units were created in vivo by transplanting isolated renal segments on three-dimensional, biodegradable polymer scaffolds. Renal segments, freshly isolated from rat kidneys, were seeded on polymer scaffolds and subcutaneously implanted in athymic mice for two and four weeks. Three-dimensional renal reconstructs were formed with glomeruli and tubules, showing a possibility of reconstituting renal structures by transplanting renal segments. |
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| Keywords: | biodegradable polymer scaffold renal reconstitution tissue engineering |
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