WD-repeat instability and diversification of the <Emphasis Type="Italic">Podospora anserina hnwd</Emphasis> non-self recognition gene family |
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Authors: | Damien Chevanne Sven J Saupe Corinne Clavé Mathieu Paoletti |
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Institution: | 1.Laboratoire de Génétique Moléculaire des Champignons,IBGC, UMR 5095 Université Victor Segalen Bordeaux2 et CNRS,Bordeaux Cedex,France |
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Abstract: | Background Genes involved in non-self recognition and host defence are typically capable of rapid diversification and exploit specialized
genetic mechanism to that end. Fungi display a non-self recognition phenomenon termed heterokaryon incompatibility that operates
when cells of unlike genotype fuse and leads to the cell death of the fusion cell. In the fungus Podospora anserina, three genes controlling this allorecognition process het-d, het-e and het-r are paralogs belonging to the same hnwd gene family. HNWD proteins are STAND proteins (signal transduction NTPase with multiple domains) that display a WD-repeat
domain controlling recognition specificity. Based on genomic sequence analysis of different P. anserina isolates, it was established that repeat regions of all members of the gene family are extremely polymorphic and undergoing
concerted evolution arguing for frequent recombination within and between family members. |
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