Novel lipoxygenase inhibitors, tetrapetalone B, C, and D from Streptomyces sp |
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| Authors: | Komoda Toshikazu Kishi Madoka Abe Naoki Sugiyama Yasumasa Hirota Akira |
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| Institution: | Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka, Yada, Japan. |
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| Abstract: | Three novel lipoxygenase inhibitors, tetrapetalone B (2, C(28)H(35)NO(9)), C (3, C(26)H(34)NO(8)), and D (4, C(28)H(36)NO(10)), were isolated from a culture broth of Streptomyces sp. USF-4727 that produced a lipoxygenase inhibitor tetrapetalone A (1) simultaneously. Each chemical structure was revealed by spectroscopic evidence, this suggests that these three compounds are structurally related to 1. They had a tetracyclic skeleton and a beta-D-rhodinosyl moiety. Tetrapetalone B, C, and D inhibited soybean lipoxygenase with IC(50): 320, 360, and 340 microM respectively. |
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