Increase in urinary markers during the acute phase reflects the degree of chronic tubulointerstitial injury after ischemia-reperfusion renal injury |
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| Authors: | Mikako Hisamichi Takeshi Sugaya Daisuke Ichikawa Seiko Hoshino Kazuaki Hirata |
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| Institution: | 1. Department of Internal Medicine, From the Division of Nephrology and Hypertension, St. Marianna University School of Medicine, Kanagawa, Japan;2. Department of Anatomy, St. Marianna University School of Medicine, Kanagawa, Japan |
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| Abstract: | Context: Acute kidney injury (AKI) could lead to progressive chronic kidney disease (CKD). Objectives: To demonstrate that urinary markers in AKI are associated with the degree of persistent renal injury. Material and methods: Human L-FABP chromosomal transgenic (Tg) mice were subjected to ischemia-reperfusion (I/R) clamping renal pedicle for 20?min or 30?min. Kidneys were obtained at one and 40 days after I/R. Results: Urinary L-FABP, NGAL, Kim-1 and albumin levels increased during the acute phase and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase. Discussion and conclusion: These markers could detect higher risk of progression to CKD. |
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| Keywords: | Acute kidney injury AKI to CKD transition chronic kidney disease renal damage |
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