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Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study |
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| Authors: | Christoph Bickel Renate B. Schnabel Tanja Zeller Karl J. Lackner Hans J. Rupprecht Stefan Blankenberg |
| Affiliation: | 1. Department of Internal Medicine, Federal Armed Forces Central Hospital, Koblenz, Germany;2. Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany;3. Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg-University Mainz, Mainz, Germany;4. Department of Medicine II, GPR Rüsselsheim, Rüsselsheim, Germany |
| Abstract: | Context: Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions. Objective: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N?=?1907). Methods: AtheroGene is a contemporary CAD cohort study (N?=?3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years. Results: Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR?=?1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients. Conclusion: In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction. |
| Keywords: | Cardiovascular events coronary artery disease leptin prognosis |