Development of GRAS strains for nutraceutical production using systems and synthetic biology approaches: advances and prospects |
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| Authors: | Long Liu Ningzi Guan Jianghua Li Hyun-dong Shin Jian Chen |
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| Institution: | 1. Key Laboratory of Carbohydrate Chemistry and Biotechnology and;2. Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China,;3. Synergetic Innovation of Center of Food Safety and Nutrition, Jiangnan University, Wuxi, China, and;4. Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China,;5. School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA |
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| Abstract: | Nutraceuticals are food substances with medical and health benefits for humans. Limited by complicated procedures, high cost, low yield, insufficient raw materials, resource waste, and environment pollution, chemical synthesis and extraction are being replaced by microbial synthesis of nutraceuticals. Many microbial strains that are generally regarded as safe (GRAS) have been identified and developed for the synthesis of nutraceuticals, and significant nutraceutical production by these strains has been achieved. In this review, we systematically summarize recent advances in nutraceutical research in terms of physiological effects on health, potential applications, drawbacks of traditional production processes, characteristics of production strains, and progress in microbial fermentation. Recent advances in systems and synthetic biology techniques have enabled comprehensive understanding of GRAS strains and its wider applications. Thus, these microbial strains are promising cell factories for the commercial production of nutraceuticals. |
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| Keywords: | GRAS strain microbial cell factory nutraceuticals synthetic biology systems biology |
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