Polyacrylates of noble metals as potential antitumor drugs |
| |
| Authors: | L A Ostrovskaya M G Voronkov D B Korman N V Bluhterova M M Fomina V A Rikova K A Abzaeva L V Zhilitskaya |
| |
| Institution: | 1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119334, Russia
2. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, Irkutsk, 664033, Russia
|
| |
| Abstract: | The antitumor activity of polyacrylates of the noble metals containing argentum (argacryl), aurum (auracryl) and platinum (platacryl) has been studied using experimental murine solid tumor models (Lewis lung carcinoma and Acatol adenocarcinoma). It has been found that polyacrylates of the noble metals are capable of inhibiting tumor development by 50–90% compared to control. Auracryl that inhibits the growth of Lewis lung carcinoma and Acatol adenocarcinoma by 80 and 90%, respectively, compared to control is the most efficient among the tested compounds and can be recommended for the further profound preclinical studies. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
