Synthesis of water-soluble ruthenium porphyrins as DNA cleavers and potential cytotoxic agents |
| |
| Authors: | Markus Hartmann Anne Robert Victor Duarte Bernhard K Keppler B Meunier |
| |
| Institution: | Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, F-31077 Toulouse cedex 4, France, FR
Anorganisch-Chemisches Institut, Universit?t Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany, DE
|
| |
| Abstract: | Three new water-soluble ruthenium porphyrin complexes have been prepared and characterized, one with a cationic ligand, Ru(TMPyP),
and two others with anionic ligands, Ru(p–COOH-PP) and Ru(TPPS). These different complexes and their manganese and iron analogues were tested in vivo as potential
antitumor agents with mice bearing P388 leukemia cells, but these complexes have no significant antitumor activity. The nuclease
activity of Ru(TMPyP) and Ru(p–COOH-PP) was evaluated on supercoiled plasmid DNA after activation by a reducing agent (ascorbate) in the presence of air
or by potassium monopersulfate. No significant activity was evidenced for these ruthenium complexes, in contrast with the
already known nuclease activity of the manganese and iron derivatives of TMPyP.
Received: 15 November 1996 / Accepted: 7 April 1997 |
| |
| Keywords: | Water-soluble rutheniumporphyrins Artificial nucleases DNA cleavage |
| 本文献已被 SpringerLink 等数据库收录！ |
|
