An ultrastructural study of macrophage-mediated resorption of calcified tissue |
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| Authors: | Barry R Rifkin DDS D Ph Richard L Baker Stephen J Coleman |
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| Institution: | (1) Departments of Pathology, University of Rochester, School of Medicine and Dentistry, 14642 Rochester, New York, USA;(2) Department of Dental Research, University of Rochester, School of Medicine and Dentistry, 14642 Rochester, New York, USA |
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| Abstract: | Summary Ultrastructural observations on macrophage-mediated resorption of calcified tissue of killed fetal long bones are described and correlated with increased 45Ca release into the medium. Macrophages disrupt calcified tissue extracellularly and appear to engulf large fragments of mineralized matrix. Ruffled borders, which are common features of osteoclasts at sites of resorption of bone, do not develop in macrophages. However, clear zones are seen in macrophages as well as osteoclasts. These findings provide additional evidence for non-osteoclast-mediated resorption of calcified tissue.This study was supported by Grant DE-04443 from USPHS |
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| Keywords: | Macrophage Osteoclast Bone resorption Electron microscopy |
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