| 三七皂苷Rg1对tPA和PAI-1活性的调节作用 |
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| 引用本文： | 詹合琴,杨锦南,沈志强. 三七皂苷Rg1对tPA和PAI-1活性的调节作用[J]. 天然产物研究与开发, 2006, 18(4): 566-568,623 |
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| 作者姓名： | 詹合琴 杨锦南 沈志强 |
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| 作者单位： | 1. 新乡医学院药理教研室,新乡,453003
2. 昆明医学院云南省天然药物药理重点实验室,昆明,650031 |
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| 基金项目： | Acknowledgements We thank Prof. Zhan Er-yi （Kunming Medical College） for providing Panax notoginsenoside Rg1. |
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| 摘 要： | 探讨三七皂苷Rg1对组织型纤溶酶原激活物(tPA)和纤溶酶原激活物抑制物(PAI-1)活性的调节作用。运用发色底物方法测定三七皂苷Rg1在体外和静脉注射对家兔血浆纤溶酶原激活物(tPA)和血浆或血小板释放的纤溶酶原激活物抑制物(PAI-1)水平的影响。结果表明,三七皂苷Rg1在体外呈浓度依赖性明显抑制血浆PAI-1活性,同时提高血浆tPA活性;30和60 mg/kg的三七皂苷Rg1静脉注射显著抑制血浆PAI-1活性,提高血浆tPA活性,同时降低凝血酶激活的血小板所释放的PAI-1水平。本实验提示三七皂苷Rg1能抑制PAI-1活性,同时升高tPA活性可能是其抗血栓作用的分子机制之一。
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| 关 键 词： | 三七皂苷Rg1 组织型纤溶酶原激活物 纤溶酶原激活物抑制物-1 家兔 血小板 |
| 文章编号： | 1001-6880（2006）04-0566-04 |
| 收稿时间： | 2005-06-20 |
| 修稿时间： | 2005-06-202005-08-05 |
PAI-1 and Tpa Modulating Activity of Panax notoginsenoside Rg1 |
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| ZHAN He-qin,YANG Jin-nan,SHEN Zhi-qiang. PAI-1 and Tpa Modulating Activity of Panax notoginsenoside Rg1[J]. Natural Product Research and Development, 2006, 18(4): 566-568,623 |
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| Authors: | ZHAN He-qin YANG Jin-nan SHEN Zhi-qiang |
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| Affiliation: | 1. Department of Pharmacology, Xinxiang Medical College, Xinxiang 453003, China; 2. Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming 650031, China |
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| Abstract: | The modulating activity of Panax notoginsenoside Rg_1 on type 1 plasminogen activator inhibitor(PAI-1) and tissue-type plasminogen activator(tPA) was investigated.The activity of PAI-1 in rabbit plasma or platelet-released substances and tPA in rabbit plasma was assayed using chromogenic substrate,in vitro or in vivo.The results showed that Panax notoginsenoside Rg_1,in vitro,significantly inhibited PAI-1 activity in plasma while elevating plasma tPA activity,in a concentration-dependent manner.Intravenous injection of Panax notoginsenoside Rg_1 at 30 and 60 mg/kg markedly suppressed PAI-1 level in plasma as well as platelet-released substances stimulated by thrombin,while increasing plasma tPA activity.It is suggested that Panax notoginsenoside Rg_1 inhibited PAI-1 activity and increased tPA activity,and this property of Panax notoginsenoside Rg_1 is advantageous to its antithrombotic effect. |
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| Keywords: | Panax notoginsenoside Rg_1 tissue type plasminogen activator type 1 plasminogen activator inhibitor rabbits platelets |
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