Optimization based automated curation of metabolic reconstructions |
| |
| Authors: | Vinay Satish Kumar Madhukar S Dasika Costas D Maranas |
| |
| Institution: | (1) Department of Industrial and Manufacturing Engineering, The Pennsylvania State University, University Park, 16802 PA, USA;(2) Department of Industrial and Manufacturing Engineering, The Pennsylvania State University, University Park, 16802 PA, USA |
| |
| Abstract: | Background Currently, there exists tens of different microbial and eukaryotic metabolic reconstructions (e.g., Escherichia coli, Saccharomyces cerevisiae, Bacillus subtilis) with many more under development. All of these reconstructions are inherently incomplete with some functionalities missing
due to the lack of experimental and/or homology information. A key challenge in the automated generation of genome-scale reconstructions
is the elucidation of these gaps and the subsequent generation of hypotheses to bridge them. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
