Structural disorder promotes assembly of protein complexes |
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Authors: | Hedi Hegyi Eva Schad Peter Tompa |
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Institution: | (1) Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary |
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Abstract: | Background The idea that the assembly of protein complexes is linked with protein disorder has been inferred from a few large complexes,
such as the viral capsid or bacterial flagellar system, only. The relationship, which suggests that larger complexes have
more disorder, has never been systematically tested. The recent high-throughput analyses of protein-protein interactions and
protein complexes in the cell generated data that enable to address this issue by bioinformatic means. |
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Keywords: | |
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