Cellular responses to methylcholanthrene; the role of benzpyrene hydroxylase in the binding of polycyclic hydrocarbon to cytosol macromolecules in fetal rat liver explants |
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| Authors: | K Bürki R A Seibert E Bresnick |
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| Affiliation: | Department of Cell and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30902 U.S.A. |
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| Abstract: | Fetal rat liver was maintained in culture over a period of several days using a simple expiant technique. The addition of 3-methylcholanthrene to the expiants caused a reproducible “induction” of benzpyrene (BP) hydroxylase. In preincubated explants, a 4- to 6-fold elevation in enzyme activity was obtained within 24–36 hr. |
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