Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions |
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Authors: | Yufei Yang Mo Hu Kaiwen Yu Xiangmei Zeng Xiaoyun Liu |
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Institution: | Institute of Analytical Chemistry and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China |
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Abstract: | Elucidation of molecular mechanisms underlying hostpathogen interactions is important for control and treatment of infectious diseases worldwide. Within the last decade, mass spectrometry (MS)-based proteomics has become a powerful and effective approach to better understand complex and dynamic host-pathogen interactions at the protein level. Herein we will review the recent progress in proteomic analyses towards bacterial infection of their mammalian host with a particular focus on enteric pathogens. Large-scale studies of dynamic proteomic alterations during infection will be discussed from the perspective of both pathogenic bacteria and host cells. |
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Keywords: | mass spectrometry proteomics bacterial infection host-pathogen interactions |
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