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Synthesis and biological evaluation of 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxins as potential anticancer agents |
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| Authors: | Reddy Pitta Bhaskar Agrawal Satyam Kumar Singh Swaran Bhat Bilal A Saxena Ajit K Kumar Halmuthur M Sampath Qazi Gulam N |
| Institution: | Department of Synthetic Chemistry, Indian Institute of Integrative Medicine, Jammu-Tawi 180001, India. |
| Abstract: | A series of novel 4beta-(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin derivatives were synthesized by employing Cu(I)-catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT-29, HCT-15, 502713, HOP-62, A-549, MCF-7, and SF-295). The compounds 9b, 9c, 9e, 9f, and 9h showed significant cytotoxic activities especially against HT-29, HCT-15, 502713 cell lines. |
| Keywords: | Podophyllotoxin ‘Click chemistry’ Cycloadditions Copper catalyst Cytotoxic activity |
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