Cell volume regulation: osmolytes, osmolyte transport, and signal transduction |
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Authors: | F Wehner H Olsen H Tinel E Kinne-Saffran and R K H Kinne |
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Institution: | (1) Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Str. 11, 44227 Dortmund, Germany;(2) Institute of Cardiovascular Research II, Bayer AG Wuppertal, 42096 Wuppertal, Germany |
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Abstract: | In recent years, it has become evident that the volume of a given cell is an important factor not only in defining its intracellular
osmolality and its shape, but also in defining other cellular functions, such as transepithelial transport, cell migration,
cell growth, cell death, and the regulation of intracellular metabolism. In addition, besides inorganic osmolytes, the existence
of organic osmolytes in cells has been discovered. Osmolyte transport systems—channels and carriers alike—have been identified
and characterized at a molecular level and also, to a certain extent, the intracellular signals regulating osmolyte movements
across the plasma membrane. The current review reflects these developments and focuses on the contributions of inorganic and
organic osmolytes and their transport systems in regulatory volume increase (RVI) and regulatory volume decrease (RVD) in
a variety of cells. Furthermore, the current knowledge on signal transduction in volume regulation is compiled, revealing
an astonishing diversity in transport systems, as well as of regulatory signals. The information available indicates the existence
of intricate spatial and temporal networks that control cell volume and that we are just beginning to be able to investigate
and to understand.
E. Kinne-Saffran deceased on December 6, 2002 |
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