Behavioral effect of mouse fibrinopeptide A on mouse forced swimming |
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| Authors: | Masuda Y Kawarada Y Sugiyama T |
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| Institution: | Psychosomatic Division, Akita University School of Medicine, Hondo 1-1-1, 010-8543, Akita, Japan. |
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| Abstract: | A specific dopamine 2 receptor antagonist, (-)sulpiride, induced an anti-depressive behavior, climbing, in mice forced to swim for 6 h after the injection. The effective fraction was divided from the mouse serum using an ion exchanger and an ultra filtration method. This fraction contained fibrinopeptide A. A peptide synthesized according to the primary 6-amino acid sequence (TDTEDK) of fibrinopeptide A also remarkably increased the behavior. The present findings clearly indicate that a peptide with TDTEDK showed anti-depressive activity. |
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