Maged1, a new regulator of skeletal myogenic differentiation and muscle regeneration |
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| Authors: | Tuan HN Nguyen Mathieu JM Bertrand Christiane Sterpin Younes Achouri Olivier RY De Backer |
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| Affiliation: | 1.URPHYM (Unité de Recherche en Physiologie Moléculaire),NARILIS (Namur Research Institute for Life Sciences), FUNDP school of Medicine, University of Namur,Namur,Belgium;2.Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research,VIB,Ghent,Belgium;3.Department of Biomedical Molecular Biology,Ghent University,Ghent,Belgium;4.Christian de Duve Institute of Cellular Pathology,Université Catholique de Louvain (UCL),Brussels,Belgium |
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| Abstract: | Background In normal adult skeletal muscle, cell turnover is very slow. However, after an acute lesion or in chronic pathological conditions, such as primary myopathies, muscle stem cells, called satellite cells, are induced to proliferate, then withdraw definitively from the cell cycle and fuse to reconstitute functional myofibers. |
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