Atrial natriuretic peptide binding sites in the mammalian heart: Localization to endomural vessels |
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Authors: | Dr. Mark G. Currie Howard Schomer Katherine L. Lanier-Smith David A. Baron |
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Affiliation: | (1) Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina, USA;(2) Department of Anatomy and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA;(3) Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 29425 Charleston, South Carolina, USA |
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Abstract: | Summary The distribution of binding sites for atrial natriuretic peptide in cardiac ventricles of several mammalian species, including rat and human, was determined by in vitro autoradiography. The results revealed a unique anatomic localization of atrial natriuretic peptide binding sites to endomural vessels (Thebesian vessels), which communicate directly with the ventricular chambers. Digital image analysis indicated that these vascular channels possessed binding site densities comparable to those of the renal glomeruli a major target site for circulating atrial natriuretic peptide. In contrast, no specific labeling of branches of the coronary arteries and veins was detected. The discrete localization of atrial natriuretic peptide binding sites to this primitive cardiac circulatory system allows speculation as to the role of this hormone in the regulation of endocardialcirculation during cardiac development, normal ventricular function, and in coronary insufficiency. |
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Keywords: | Atrial natriuretic peptide Receptors Autoradiography Heart Endocardium Rat (Sprague-Dawley) Human |
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