Cytogenetic studies of a family with trisomy 21 mosaicism in two successive generations as the cause of Down's syndrome |
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Authors: | W Werner F H Herrmann B John |
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Institution: | (1) Abteilung Medizinische Genetik, Medizinische Akademie Erfurt, Klement-Gottwald-Str. 34, DDR-5080 Erfurt, German Democratic Republic |
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Abstract: | Summary A family with trisomy-21 mosaicism in two successive generations and a Down's syndrome child in the third generation is presented. Cytogenetic studies of eight individuals of this family showed a marker chromosome 15ph+ and a heteromorphic chromosome 18 in some members. The standard trisomy 21 in the proband was derived from a trisomy-21 oogonium by secondary nondisjunction in his mother. |
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