Selenium in the anterior pituitary of the rat after a single injection of75Se sodium selenite |
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Authors: | O Thorlacius-Ussing F Taagehøj Jensen |
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Institution: | 1. Institute of Anatomy B (Neurobiology), University of Aarhus, DK-8000, Aarhus C, Denmark 2. Dept. of Nuclear Medicine, Aarhus Municipal Hospital, DK-8000, Aarhus C, Denmark
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Abstract: | In order to investigate the selenite metabolism in the anterior pituitary and compare it with other endocrine organs, rats
were injected intraperitoneally with75Se sodium selenite (5 mg/kg). The rats were whole body counted shortly after injection and recounted just before sacrifice,
which was performed 2, 24, 48 h, and 4, 10, 20, 30, 40, 60, and 80 d after injection. Besides the anterior pituitary, the
selenium content was also estimated in the thyroid gland, testis, adrenals, liver, kidney, and blood. The maximum selenium
content was observed in all organs 2 h after injection, at which time the anterior pituitary contained 2.9 μg/g wet wt, compared
to 13.5 μ/g wet wt in liver and .6 μg/mg wet wt in testis.
The excretion of selenite from the anterior pituitary resembled that seen in most other organs investigated, i.e., an initial
rapid excretion and a slower secondary phase resembling a first order reaction. Practically all selenium was excreted by 60
d after injection. |
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Keywords: | Index Entries" target="_blank">Index Entries Anterior pituitary of rat selenium in after injection of75Se sodium selenite |
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