Vicia faba root tip micronucleus test on the mutagenicity of water-soluble contents of cigarette smoke |
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| Institution: | 1. Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, China;2. Experimental Teaching Center, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China;1. Research Center for Environmental Health Technology, Iran University of Medical Sciences, Tehran, Iran;2. Department of Environmental Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;3. Student Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran;4. Department of Chemistry, Payame Noor University, Tehran, Iran;1. School of Geography, Earth & Environmental Sciences and Birmingham Institute of Forest Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom;2. Karlsruhe Institute of Technology, Institute of Meteorology and Climate Research-Atmospheric Environmental Research (IMK-IFU), Kreuzeckbahnstraße 19, 82467 Garmisch-Partenkirchen, Germany;3. Potsdam Institute for Climate Impact Research, Potsdam, Germany;4. CSIRO Oceans and Atmosphere, P.O. Box 3023, Canberra ACT 2601, Australia;5. Department of Physical Geography and Ecosystem Science, Lund University, SE-223 62 Lund, Sweden;1. CIRAD, UMR 108 AGAP, F-34398 Montpellier, France;2. INRAE, UMR 759 LEPSE, Institut de Biologie Intégrative des Plantes, F-34060 Montpellier, France;3. Centre for Crop Systems Analysis, Dept. Plant Sciences, Wageningen University & Research, Wageningen, The Netherlands;4. Plant Science, Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, United Kingdom;1. MilliporeSigma, 645 Elliott Ave W, Suite 100, Seattle, WA, 98119, USA;2. Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, Ontario, K1A 1C1, Canada;3. Genome Health Foundation, North Brighton, SA, 5048, Australia |
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| Abstract: | The possible mutagenicity of the water-soluble contents of cigarette smoke (WSCS) was evaluated by using the Vicia faba root tip micronucleus test. The results showed significant changes in micronucleus frequency which were caused by each different concentration of WSCS. This indicates that the Vicia faba root tip micronucleus test might be used as one kind of mutagenic detection method for cigarette smoke. A comparative evaluation on the mutagenicity of 10 brands of cigarettes was carried out. Results confirmed that various degrees of mutagenicity were found for all of the brand cigarettes, among them, Huaihai was the highest, while Camellia was the lowest. The micronucleus frequencies were reduced by adding tea polyphenol, nicotinamide adenine, vitamin C and sodium selenite to the WSCS. The results suggest that these added substances might reduce the genetic injury induced by cigarette smoke. |
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