Circulating LIPCAR is a potential biomarker of heart failure in patients post-acute myocardial infarction |
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Authors: | Li Yan Yu Zhang Mei Wang Lu Wang Wei Zhang Zhi-Ru Ge |
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Institution: | 1.Department of Cardiology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai 200135, China; 2.Department of Emergency Medicine, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai 200135, China; 3.The Graduate School, Ningxia Medical University, Yinchuan, Ningxia 750004, China |
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Abstract: | In heart failure (HF) patients with reduced ejection fraction, LIPCAR, a long noncoding RNA is elevated and is associated with left ventricular remodeling and poor prognosis. We studied the role of LIPCAR in patients with HF post-acute myocardial infarction (AMI) to find biomarkers for early detection of HF. We conducted a study of 127 patients with AMI, of which 59 were patients with HF post-AMI. LIPCAR levels were higher in HF patients post-AMI than patients without HF, and LIPCAR had a high predictive value for diagnosis of HF, which was estimated by receiver operating characteristic curves (AUC: 0.985). The results indicate that LIPCAR may be a marker of early HF after AMI. |
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Keywords: | LIPCAR biomarker acute myocardial infarction heart failure |
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