Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum |
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Authors: | van Gils Marit J Edo-Matas Diana Bowles Emma J Burger Judith A Stewart-Jones Guillaume B Schuitemaker Hanneke |
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Institution: | Department of Experimental Immunology, Academic Medical Center, AZ Amsterdam, The Netherlands. |
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Abstract: | Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential N-linked glycosylation sites, and showed lower replication kinetics than successfully evolving HIV-1 variants. These data reflect the host selection pressures on phenotypic characteristics of HIV-1 and illustrate in detail the dynamic interaction between HIV-1 and its host's humoral immune responses. |
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