Role of calmodulin in antidiuretic hormone mediated water transport |
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| Authors: | Renaud Beauwens Marc Rentmeesters |
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| Affiliation: | 1. Department of Medicine and Physiology University of Iowa College of Medicine Iowa City, Iowa, USA;2. Department of Physiology University of Louvain Medical School B 1200, Brussels, Belgium |
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| Abstract: | Several classes of tricyclic antidepressants inhibit the action of antidiuretic hormone (ADH) and cyclic adenine monophosphate (cAMP) on osmotic water flow across toad urinary bladder without any effect on sodium transport. This finding suggests that calmodulin is involved in the hydroosmotic action of ADH (and of serosal hypertonicity), possibly in inducing exocytosis at the luminal border of vesicles rich in water channels. |
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