Inhibition of human fibroblasts sphingomyelinase by cholesterol and 7-dehydrocholesterol |
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Authors: | J.C. Maziere C. Wolf C. Maziere L. Mora G. Bereziat J. Polonovski |
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Affiliation: | Laboratoire de Biochimie, Faculté de Médecine St-Antoine, 27, rue Chaligny, 75012 - Paris, France |
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Abstract: | An inhibition of human fibroblast sphingomyelinase by cholesterol and 7-dehydrocholesterol is shown. This effect is obtained for cholesterol and 7-dehydrocholesterol/sphingomyelin molar ratios above 0.1. Diffusion measurements performed on mixed liposomes demonstrated for cholesterol/sphingomyelin and 7-dehydrocholesterol/sphingomyelin molar ratios above 0.1 a sharp increase in diffusion intensity. The mechanism of the inhibition of sphingomyelinase by sterols is discussed in relation to the physical state of the substrate. A possible involvement of this phenomenon in sphingomyelin accumulation observed in aging or in atheroma is discussed. |
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