Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems. |
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| Authors: | S Robb T R Cheek F L Hannan L M Hall J M Midgley P D Evans |
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| Affiliation: | AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK. |
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| Abstract: | A cloned seven transmembrane-spanning Drosophila octopamine/tyramine receptor, permanently expressed in a Chinese hamster ovary cell line, both inhibits adenylate cyclase activity and leads to the elevation of intracellular Ca2+ levels by separate G-protein-coupled pathways. Agonists of this receptor (octopamine and tyramine), differing by only a single hydroxyl group in their side chain, may be capable of differentially coupling it to different second messenger systems. Thus, a single receptor may have a different pharmacological profile depending on which second messenger system is used to assay its efficacy. |
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