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Export of proteins across membranes: The helix reversion hypothesis |
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| Authors: | U. P. Shinde T. N. Guru Row Y. R. Mawal |
| Affiliation: | (1) Division of Chemical Engineering, National Chemical Laboratory, 411 008 Pune, India;(2) Division of Physical Chemistry, Indian Institute of Science, Bangalore;(3) Division of Biochemical Sciences, Division of Chemical Engineering, National Chemical Laboratory, 411 008 Pune, India |
| Abstract: | A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export. |
| Keywords: | protein export conformational changes leader peptides hairpin helix |
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