Detection of influenza A in clinical specimens and cell culture fluid by a commercial EIA |
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Authors: | Gleaves C A Brown J A |
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Institution: | Clinical Microbiology, Section of Infectious Diseases, Providence medical Center, Portland, OR 97213, USA. |
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Abstract: | A MoAb-based capture EIA for the direct detection of influenza A from clinical samples was compared with cell culture isolation. A total of 330 respiratory specimens were submitted for detection of influenza A and/or other respiratory viruses. Influenza A was detected in 39 of 330 (12%) respiratory samples by culture or EIA. There were 33 concordant (EIA+/Culture-) samples (82%), and 6 discordant samples (3 EIA +/Culture-; 3 EIA-/Culture+). Compared to viral isolation, the EIA had a sensitivity of 92%, a specificity of 98%, with positive and negative predictive values of 92% and 99%, respectively. |
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