Protein-derived cofactors. Expanding the scope of post-translational modifications |
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Authors: | Davidson Victor L |
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Institution: | Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. vdavidson@biochem.umsmed.edu |
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Abstract: | Recent advances in enzymology, structural biology, and protein chemistry have extended the scope of the field of cofactor-dependent enzyme catalysis. It has been documented that catalytic and redox-active prosthetic groups may be derived from post-translational modification of amino acid residues of proteins. These protein-derived cofactors typically arise from the oxygenation of aromatic residues, covalent cross-linking of amino acid residues, or cyclization or cleavage of internal amino acid residues. In some cases, the post-translation modification is a self-processing event, whereas in others, another processing enzyme is required. The characterization of protein-derived cofactors and their mechanisms of biogenesis introduce a new dimension to our current views about protein evolution and protein structure-function relationships. |
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