Changes in hemorheological parameters due to lead exposure in female rats |
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Authors: | Selmin Toplan Dervis
zcelik Tevfik Gulyasar Mehmet Can Akyolcu |
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Institution: | Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, 34303 Istanbul, Turkey. toplan@istanbul.edu.tr |
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Abstract: | Lead is an ubiquitous metal in the environment that induces a broad range of physiological, biochemical and behavioral dysfunctions. The purpose of this study was to investigate its effects on blood parameters and blood viscosity. Female rats (14 Wistar-Albino type) were divided into a control and a lead exposed group. Both groups were fed with the same standard food, but lead acetate was added to the drinking water of the experimental group for 5 weeks. At the end of the experimental period, blood samples were drawn from the abdominal aorta of the anaesthetized animals. Hematocrit (Hct %), hemoglobin (Hb), and the number of erythrocytes were determined, blood viscosity was measured with a rotational viscometer, and the lead concentration in blood was analyzed by means of flame atomic absorption spectrometry. The erythrocyte count, Hb and Hct % of the lead exposed group were found to be significantly lower than in the control group (p<0.01). The blood viscosity level was significantly higher compared to the control group (p<0.01). It can be concluded that increased lead concentrations in blood impair certain hemorheological mechanisms and increase blood viscosity. |
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Keywords: | Lead Blood viscosity Hemorheology Hematocrit Hemoglobin Erythrocytes |
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