Identification and biological evaluation of grapefruit oil components as potential novel efflux pump modulators in methicillin-resistant Staphylococcus aureus bacterial strains |
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Authors: | Abulrob Abedel-Nasser Suller Marc T E Gumbleton Mark Simons Claire Russell A Denver |
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Institution: | Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3XF, UK. |
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Abstract: | Methicillin-resistant Staphylococcus aureus (MRSA) and MSSA strains were treated with: (a) grapefruit oil (GFO) components, isolated by chromatography and characterised by NMR and mass spectroscopy; (b) antimicrobial agents, or (c) a combination of both to evaluate (MIC determination) intrinsic antibacterial activity and to determine whether GFO components could modulate bacterial sensitivity to the anti-bacterial agents. Preliminary data suggested that the grapefruit component 4-(E)-5-(3,3-dimethyl-2-oxiranyl)-3-methyl-2-pentenyl]oxy]-7H-furo3,2-g]chromen-7-one (2) enhances the susceptibility of test MRSA strains to agents, e.g., ethidium bromide and norfloxacin, to which these micro-organisms are normally resistant. |
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Keywords: | Grapefruit oil Efflux pump modulators 4-{[(E)-5-(3 3-Dimethyl-2-oxiranyl)-3-methyl-2-pentenyl]oxy}-7H-furo[3 2-g]chromen-7-one (bergamottin epoxide) MRSA and MSSA strains |
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