CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses |
| |
Authors: | Sun Xun Yamada Hisakata Shibata Kensuke Muta Hiromi Tani Kenzaburo Podack Eckhard R Iwakura Yoichiro Yoshikai Yasunobu |
| |
Affiliation: | Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. |
| |
Abstract: | We have previously found that CD30 ligand (CD30L; CD153)/CD30 signaling executed by the T-T cell interaction plays a critical role in Th17 cell differentiation, at least partly via downregulation of IL-2 production. In this study, we investigated the role of CD30L in the development of colitis experimentally induced by dextran sulfate sodium (DSS), in which IL-17A is involved in the pathogenesis. CD30L(-/-) mice were resistant to both acute colitis induced by administration of 3 to ~ 5% DSS and to chronic colitis induced by administration of 1.5% DSS on days 0-5, 10-15, and 20-25 as assessed by weight loss, survival rate, and histopathology. The levels of IFN-γ, IL-17A, and IL-10 were significantly lower but the IL-2 level higher in the lamina propria T lymphocytes of CD30L(-/-) mice than those in lamina propria T lymphocytes of wild-type mice after DSS administration. Soluble murine CD30-Ig fusion protein, which was capable of inhibiting Th17 cell differentiation in vitro, ameliorated both types of DSS-induced colitis in wild-type mice. Modulation of CD30L/CD30 signaling by soluble CD30 could be a novel biological therapy for inflammatory diseases associated with Th17 responses. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|