Ultrastructural and cytochemical studies of acid phosphatase and trimetaphosphatase in rat peritoneal mast cells developing in vivo |
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| Authors: | Maria Celia Jamur Ithamar Vugman Dr Arthur R Hand |
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| Institution: | (1) Departamento de Morfologia, Faculdade de Medicina de Ribeirão Preto, São Paulo, Brasil;(2) Laboratory of Oral Biology and Physiology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA;(3) National Institute of Dental Research, National Institutes of Health, Building 30, Room 211, 20892 Bethesda, MD, USA;(4) Present address: Departamento de Ciencias Morfologicas, Setor de Ciencias Biologicas, Universidade Federal do Parana, Brasil |
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| Abstract: | Summary The ultrastructural and cytochemical features of peritoneal mast cells of the rat were studied. Immature mast cells show specific cytoplasmic granules of different sizes, the smaller ones localized in the Golgi region. The rough endoplasmic reticulum and Golgi apparatus are well developed, and mitochondria are numerous. Nuclei show deep indentations. Acid phosphatase is present in the Golgi saccules, in GERL (Golgi apparatus-endoplasmic reticulumlysosome) and in some small granules. It is not present in mature granules. Trimetaphosphatase is present in the Golgi saccules, in GERL, in most immature granules and in some mature granules. These enzymes appear to be transported and packaged into granules by the Golgi apparatus, suggesting that the specific mast cell granules may be a form of lysosome. The results of this study are consistent with the hypothesis that peritoneal mast cells may be derived from macrophage-like precursors. |
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| Keywords: | Mast cell maturation Mast cell granules Acid hydrolases Lysosomes Golgi apparatus |
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