Purification and crystallization of thymidine kinase from herpes simplex virus type 1 |
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| Authors: | M R Sanderson P S Freemont H M Murthy J F Krane W C Summers T A Steitz |
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| Affiliation: | Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CN 06511. |
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| Abstract: | Thymidine kinase from herpes simplex virus type 1 (ATP:thymidine 5'-phosphotransferase; EC 2.7.1.21) has been purified from an overexpression system and crystallized against ammonium sulfate by using the hanging-drop technique. The tetragonal crystals are of space group P4122 or P4322, and have unit cell dimensions a = b = 84 A, c = 180 A. |
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