Synthesis and cytotoxic activities of new fatty acid esters of 20(S)-protopanaxadiol |
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| Authors: | Li Ning Huang Yuan Xiao Wan Liu Jinping Li Xian Li Pingya |
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| Institution: | School of Traditional Chinese Materia Medica 49#, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China. liningsypharm@163.com |
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| Abstract: | In order to find new lead compounds with antitumour activies, thirteen new fatty acid esters of 20(S)-protopanaxadiol (PPD) were synthesized using oleoyl chloride or fatty acids and N,N'-dicyclohexylcarbodiimide (DCC). Their cytotoxic activities were tested using the MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] method, and the structure-activity relationships between the fatty acid esters of PPD and their cytotoxic activities are discussed. |
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